(FBIOyF) Departamento de Química Orgánica
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Ítem Acceso Abierto 3-methylcrotonyl Coenzyme A (CoA) carboxylase complex is involved in the Xanthomonas citri subsp. citri lifestyle during citrus infection(Public Library of Science (PLOS), 2018-06-07) Tomassetti, Mauro; Garavaglia, Betiana Soledad; Vranych, Cecilia Verónica; Gottig, Natalia; Ottado, Jorgelina; Gramajo, Hugo Cesar; Diacovich, LautaroÍtem Acceso Abierto A coiled coil switch mediates cold sensing by the thermosensory protein DesK(Wiley, 2015-10-08) Saita, Emilio Adolfo; Abriata, Luciano Andrés; Tsai, Yi-Ting; Trajtenberg, Felipe; Lemmin, Thomas; Buschiazzo, Alejandro; Dal Peraro, Matteo; De Mendoza, Diego; Albanesi, DanielaThe thermosensor histidine kinase DesK from Bacillus subtilis senses changes in membrane fluidity initiating an adaptive response. Structural changes in DesK have been implicated in transmembrane signaling, but direct evidence is still lacking. On the basis of structure-guided mutagenesis, we now propose a mechanism of DesK-mediated signal sensing and transduction. The data indicate that stabilization/destabilization of a 2-helix coiled coil, which connects the transmembrane sensory domain of DesK to its cytosolic catalytic region, is crucial to control its signaling state. Computational modeling and simulations reveal couplings between protein, water and membrane mechanics. We propose that membrane thickening is the main driving force for signal sensing and that it acts by inducing helix stretching and rotation prompting an asymmetric kinase-competent state. Overall, the known structural changes of the sensor kinase, as well as further dynamic rearrangements that we now predict, consistently link structure determinants to activity modulation.Ítem Acceso Abierto A conditional mutant of the fatty acid synthase unveils unexpected cross talks in mycobacterial lipid metabolism(Royal Society, 2017-02-22) Cabruja, Matías Ezequiel; Mondino, Sonia Soledad; Tsai, Yi-Ting; Lara, María Julia; Gramajo, Hugo Cesar; Gago, GabrielaÍtem Acceso Abierto A convenient and eco-friendly cerium(III) chloride-catalysed synthesis of methoxime derivatives of aromatic aldehydes and ketones(The Royal Society, 2018-05-23) Cortés, Iván; Kaufman, Teodoro Saúl; Bracca, Andrea Beatriz JuanaÍtem Acceso Abierto A convenient approach to an advanced intermediate toward the naturally occurring, bioactive 6-substituted 5-hydroxy-4-aryl-1H-quinolin-2-ones(Royal Society of Chemistry, 2016-01-26) Simonetti, Sebastián Osvaldo; Larghi, Enrique Leandro; Kaufman, Teodoro SaúlÍtem Acceso Abierto A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062(MDPI, 2017-07-12) Li, Chun-shun; Sarotti, Ariel Marcelo; Yang, Baojun; Turkson, James; Cao, ShugengÍtem Acceso Abierto A novel multidomain acyl-CoA carboxylase in Saccharopolyspora erythraea provides malonyl-CoA for de novo fatty acid biosynthesis(Nature, 2019-04-30) Livieri, Andrea L.; Navone, Laura; Marcellin, Esteban; Gramajo, Hugo Cesar; Rodriguez, EduardoÍtem Acceso Abierto A study of the heat-mediated phase transformations of praziquantel hydrates. Evaluation of their impact on the dissolution rate(Elsevier, 2022-11) Salazar Rojas, Duvernis; Kaufman, Teodoro Saúl; Maggio, Rubén MarianoÍtem Acceso Abierto A synthetic approach to PW2‐Like compounds(Wiley, 2020-02-05) Forastieri, Pamela S.; Luna, Liliana E.; Cravero, Raquel M.; Labadie, Guillermo RobertoÍtem Acceso Abierto A theoretical study of the Duff reaction : insights into its selectivity(Royal Society of Chemistry, 2016-10-07) Grimblat, Nicolás; Sarotti, Ariel Marcelo; Kaufman, Teodoro Saúl; Simonetti, Sebastián OsvaldoÍtem Acceso Abierto An introductory classroom exercise on protein molecular model visualization and detailed analysis of protein–ligand binding(Wiley, 2013-03-23) Poeylaut-Palena, Andrés A.; Laborde, María de los ÁngelesA learning module for molecular level analysis of protein structure and ligand/drug interaction through the visualization of X-ray diffraction is presented. Using DeepView as molecular model visualization software, students learn about the general concepts of protein structure. This Biochemistry classroom exercise is designed to be carried out by following the detailed instructions that make software handling straightforward. Students learn about protein structure and gain insight into the molecular level of the interaction of two active compounds with their receptor.Ítem Acceso Abierto An update on phytochemicals and pharmacological activities of the genus persicaria and polygonum(MDPI, 2021-10-01) Seimandi, Gisela; Álvarez, Norma; Stegmayer, María Inés; Fernández, Laura; Ruiz, Verónica; Favaro, María Alejandra; Derita, Marcos G.Ítem Acceso Abierto An optimized protocol for the synthesis of peptides Containing trans-Cyclooctene and Bicyclononyne Dienophiles as useful multifunctional bioorthogonal probes(John Wiley and Sons Inc, 2021-09-24) La Venia, Agustina; Dzijak, Rastislav; Rampmaier, Robert; Vrabel, MilanÍtem Acceso Abierto An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431(MDPI, 2019-01-07) Li, Chun-shun; Sarotti, Ariel Marcelo; Wu, Xiaohua; Yang, Baojun; Turkson, James; Chen, Yongfei; Liu, Qingsong; Cao, ShugengÍtem Acceso Abierto Antifungal activity and toxicity studies of flavanones isolated from Tessaria dodoneifolia aerial parts(Elsevier, 2020) Soberón, José R.; Sgariglia, Melina A.; Carabajal Torrez, José A.; Aguilar, Franco A.; Pero, Edgardo J.I.; Sampietro, Diego A.; Fernández de Luco, Julia; Labadie, Guillermo RobertoTessaria dodoneifolia [Asteraceae] is traditionally employed in Northwestern Argentina for fungal infections treatment. We report the antifungal activity guided isolation and identification of substances from aerial parts of this species, both individually and in combination with fluconazole (FLU), against Candida albicans strains. Two antifungal flavanones were identified as naringenin (NAR) and pinocembrin (PIN). These compounds could individually inhibit the growth of C. albicans strains. Combinations of NAR and PIN with FLU were synergistic against the FLU resistant and sensitive C. albicans strains. Genotoxic and cytotoxic evaluations were also performed. NAR, PIN and their combinations with FLU did not have a genotoxic effect on Bacillus subtilis rec strains. Finally, these compounds did not show cytotoxicity at concentrations below 80 μg/mL.Ítem Acceso Abierto Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs(SAGE, 2015-09-01) Campos, Adriana; Rodrigues Souza, Greice Maria; Delle Monache, Franco; Butassi, Estefanía; Zacchino, Susana; Cechinel Filho, ValdirÍtem Acceso Abierto Antimicrobial activity of quinoline-based hydroxyimidazolium hybrids(MDPI, 2019-11-28) Insuasty, Daniel; Vidal, Oscar; Bernal, Anthony; Marquez, Edgar; Guzman, Juan; Insuasty, Braulio; Svetaz, Laura Andrea ; Zacchino, Susana; Puerto, GloriaÍtem Acceso Abierto Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones(Sociedade Brasileira de Química, 2018-09-13) Vásquez-Martínez, Yesseny A.; Osorio, Mauricio E.; San Martín, Diego A.; Carvajal, Marcela A.; Vergara, Alejandra P.; Sanchez, Elizabeth; Raimondi, Marcela; Zacchino, Susana; Mascayano, Carolina; Torrent, Claudia; Cabezas, Francisco; Mejias, Sophia; Montoya, Margarita; Cortez-San Martín, MarceloÍtem Acceso Abierto Antioxidant dietary fibre recovery from Brazilian Pinot noir grape pomace(Elsevier, 2016-01-11) Beres, Carolina; Simas-Tosin, Fernanda F.; Cabezudo, Ignacio; Freitas, Suely P.; Iacomini, Marcello; Mellinger-Silva, Caroline; Cabral, Lourdes M. C.Ítem Acceso Abierto Astringency reduction in red wine by whey proteins(Elsevier, 2015-12-11) Jauregi, Paula; Olatujoye, Jumoke B.; Cabezudo, Ignacio; Frazier, Richard A.; Gordon, Michael H.