Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells
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Date
2017-02-08
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Public Library of Science (PLOS)
Abstract
Description
When an infection occurs, the innate immune cells recognize Pathogen Associated Molec ular Patterns (PAMPs) through their Pattern Recognition Receptors. This triggers an
inflammatory response intended to kill the foreign microbe. But inflammation can also be
triggered by the recognition of endogenous molecules called “Danger (or Damage) Asso ciated Molecular Patterns” (DAMPs) that are released by damaged or necrotic cells to
“ring the alarm” of the immune system that repair is needed, so some of them are also
known as “alarmins”. High Mobility group box 1 protein (HMGB1) is a prototypical alar min molecule released by injured cells and it is also actively secreted by cells of the innate
immune system in response to invasion as well as to sterile damage. Trypanosoma cruzi,
the causal agent of Chagas Disease, has its own HMGB protein that we called TcHMGB.
Using in vitro and in vivo experimental systems, we demonstrated for the first time that
TcHMGB is able to mediate inflammation on mammalian cells, inducing the expression
of both pro-inflammatory and anti-inflammatory cytokines. Our results suggest that the
parasite´s protein could have a role in the immune response and the pathogenesis of Cha gas disease, probably overlapping to some extent with the host cell DAMP molecules´
functions.
Para citar este articulo: Cribb P, Perdomo V, Alonso VL, Manarin R, Barrios-Paya´n J, Marquina-Castillo B, et al. (2017) Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells. PLoS Negl Trop Dis 11(2): e0005350. doi:10.1371/journal.pntd.0005350
Para citar este articulo: Cribb P, Perdomo V, Alonso VL, Manarin R, Barrios-Paya´n J, Marquina-Castillo B, et al. (2017) Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells. PLoS Negl Trop Dis 11(2): e0005350. doi:10.1371/journal.pntd.0005350
Keywords
High Mobility Group B Proteins, Trypanosoma cruzi, Damage-associated Molecular Patterns, Inflammation