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Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy

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dc.citation.titleNeuroimmunomodulationes
dc.citation.volumeVol.25, No. 3es
dc.creatorGonzález, Florencia Belén
dc.creatorVillar, Silvina Raquel
dc.creatorD'Attilio, Luciano
dc.creatorLeiva, Rodolfo
dc.creatorMarquez, Julia
dc.creatorLioi, Susana
dc.creatorBeloscar, Juan
dc.creatorBottasso, Oscar
dc.creatorPérez, Ana Rosa
dc.date.accessioned2019-04-15T13:35:44Z
dc.date.available2019-04-15T13:35:44Z
dc.date.issued2018-09-25
dc.descriptionIndividuals who are infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC), which is a complication involving a series of immune pathogenetic mechanisms, although an association between immune and metabolic alterations was more recently proposed. Accordingly, we investigated the immuno-metabolic response in chagasic patients and their possible influence on CCC pathogenesis. To this end, T. cruzi-seropositive (asymptomatic or with CCC) and sero-negative individuals were studied. Serum tumour necrosis factor (TNF)-α, interleukin (IL)-6, adipocytokines and the expression of their receptors in peripheral blood mononuclear cell (PBMC) were evaluated, together with other factors influencing the immune response. CCC patients showed major metabolic and hormonal abnormalities, in parallel with increased IL-6 and leptin serum levels. TNF-α receptor s, leptin and adiponectin receptors (ObR and Adipo-Rs respectively), as well as PPAR-γ expression in PBMCs from CCC patients were compatible with a counteracting response leading to an unfavourable immune-metabolic profile. These results suggest that persistently increased levels of immune-metabolic pro-inflammatory mediators along with the adverse endocrine anti-inflammatory response of CCC individuals, may contribute to the underlying mechanisms dealing with myocardial tissue damage.es
dc.description.filFil: González, Florencia Belén. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clínica y Experimental de Rosario, CONICET-UNR; Argentinaes
dc.description.filFil: Bottasso, Oscar. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clínica y Experimental de Rosario, CONICET-UNR; Argentinaes
dc.formatapplication/pdf
dc.format.extent1-10es
dc.identifier.issn1021-7401es
dc.identifier.urihttp://hdl.handle.net/2133/14381
dc.language.isoenges
dc.publisherS. Karger AGes
dc.relation.publisherversionhttps://doi.org/10.1159/000491699es
dc.rightsopenAccesses
dc.rights.holder© 2018 S. Karger AG, Baseles
dc.subjectChagas diseasees
dc.subjectImmuno-metabolismes
dc.subjectCortisoles
dc.subjectTumor necrosis factor-αes
dc.subjectInterleukin-6es
dc.subjectAdipocytokineses
dc.subjectTumor necrosis factor-α receptor type-1es
dc.titleDysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathyes
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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FCM - Instituto de Inmunología - Artículos de Investigación
CIUNR - Ciencias Naturales - Artículos de Revista