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In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium

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dc.citation.titleMicrovascular Researches
dc.citation.volume135es
dc.creatorAlet, Analía I.
dc.creatorBatista da Silva, Marcus V.
dc.creatorCastellini, Horacio V.
dc.creatorAlet, Nicolás A.
dc.creatorRiquelme, Bibiana Doris
dc.date.accessioned2021-02-23T13:21:57Z
dc.date.available2021-02-23T13:21:57Z
dc.date.issued2021-01-07
dc.descriptionSeveral studies report flow disturbance and microcirculation disorders upon anesthesia treatment. These alterations are often related to blood rheology changes. In this work, it was attempted to make a detailed description of the alterations in erythrocyte mechanical properties by the action of propofol, remifentanil, and vecuronium. For this, an in vitro study was performed on red blood cell samples from healthy donors incubated with solutions of propofol (4 μg/mL whole blood), remifentanil (10 ng/mL plasma), and vecuronium (0.15 μg/mL plasma). Erythrocyte viscoelastic parameters were determined by octuplicate using a Reómetro Eritrocitario. Also, a Wilcoxon signed rank-test with Yates correction for continuity was performed to analyze the overall alteration in the mechanical properties of erythrocytes. Statistical analysis showed that the three studied anesthetics changed the erythrocyte mechanical properties at different parts of the membrane. These results would imply an interaction of these anesthetics with the erythrocyte membrane. Finally, this could conduce to alterations in microcirculation.es
dc.description.filFil: Alet, Analía I. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.es
dc.description.filFil: Batista da Silva, Marcus V. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.es
dc.description.filFil: Castellini, Horacio V. Universidad Nacional de Rosario. Facultad de Ciencias Exactas, Ingeniería y Agrimensura; Argentina.es
dc.description.filFil: Alet, Nicolás A. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina.es
dc.description.filFil: Alet, Nicolás A. Hospital Provincial del Centenario; Argentina.es
dc.description.filFil: Riquelme, Bibiana Doris. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Física. Instituto de Física Rosario (IFIR-CONICET); Argentina.es
dc.description.sponsorshipUniversidad Nacional de Rosario: BIO400, Res. CS. N◦ 448/2017es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)es
dc.formatapplication/pdf
dc.format.extent1-15es
dc.identifier.issn0026-2862es
dc.identifier.urihttp://hdl.handle.net/2133/19671
dc.language.isoenges
dc.publisherElsevieres
dc.relation.publisherversionhttps://doi.org/10.1016/j.mvr.2021.104132es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0026286221000029?via%3Dihub#ks0010es
dc.rightsembargoedAccesses
dc.rights.holderElsevieres
dc.rights.holderAlet, Analía I.es
dc.rights.holderBatista da Silva, Marcus V.es
dc.rights.holderCastellini, Horacio V.es
dc.rights.holderAlet, Nicolás A.es
dc.rights.holderRiquelme, Bibiana Dorises
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.textAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es*
dc.subjectPropofoles
dc.subjectRemifentaniles
dc.subjectErythrocyte viscoelasticityes
dc.subjectVecuroniumes
dc.subjectHemorheologyes
dc.titleIn vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuroniumes
dc.typearticle
dc.typeartículo
dc.typeacceptedVersion
dc.type.collectionarticulo
dc.type.versionacceptedVersiones

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