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The H-NS regulator plays a role in the stress induced by carbapenemase expression in acinetobacter baumannii

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dc.citation.titlemSphere
dc.citation.volume5
dc.contributor.orcidhttps://orcid.org/0000-0002-9904-7890
dc.creatorHuang, Fanny
dc.creatorFitchett, Noelle
dc.creatorRazo Gutiérrez, Chelsea
dc.creatorLe, Casin
dc.creatorMartínez, Jasmine
dc.creatorRa, Grace
dc.creatorLópez, Carolina
dc.creatorGonzález, Lisandro Javier
dc.creatorSieira, Rodrigo
dc.creatorVila, Alejandro J.
dc.creatorBonomo, Robert A.
dc.creatorRamírez, María Soledad
dc.date.accessioned2024-06-14T16:12:13Z
dc.date.available2024-06-14T16:12:13Z
dc.date.issued2020-08-26
dc.description.abstractDisruption of the histone-like nucleoid structuring protein (H-NS) was shown to affect the ability of Gram-negative bacteria to regulate genes associated with virulence, persistence, stress response, quorum sensing, biosynthesis pathways, and cell adhesion. Here, we used the expression of metallo--lactamases (MBLs), known to elicit envelope stress by the accumulation of toxic precursors in the periplasm, to interrogate the role of H-NS in Acinetobacter baumannii, together with other stressors. Using a multidrug-resistant A. baumannii strain, we observed that H-NS plays a role in alleviating the stress triggered by MBL toxic precursors and counteracts the effect of DNA-damaging agents, supporting its role in stress response.
dc.description.filFil: Huang, Fanny. California State University. College of Natural Sciences and Mathematics. Center for Applied Biotechnology Studies. Department of Biological Science; USA.
dc.description.filFil: Fitchett, Noelle. California State University. College of Natural Sciences and Mathematics. Center for Applied Biotechnology Studies. Department of Biological Science; USA.
dc.description.filFil: Razo Gutiérrez, Chelsea. California State University. College of Natural Sciences and Mathematics. Center for Applied Biotechnology Studies. Department of Biological Science; USA.
dc.description.filFil: Le, Casin. California State University. College of Natural Sciences and Mathematics. Center for Applied Biotechnology Studies. Department of Biological Science; USA.
dc.description.filFil: Martínez, Jasmine. California State University. College of Natural Sciences and Mathematics. Center for Applied Biotechnology Studies. Department of Biological Science; USA.
dc.description.filFil: Ra, Grace. California State University. College of Natural Sciences and Mathematics. Center for Applied Biotechnology Studies. Department of Biological Science; USA.
dc.description.filFil: López, Carolina. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.filFil: González, Lisandro Javier. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.filFil: González, Lisandro Javier. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Biofísica; Argentina.
dc.description.filFil: Sieira, Rodrigo. Fundación Instituto Leloir; Argentina.
dc.description.filFil: Vila, Alejandro J. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.filFil: Vila, Alejandro J. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Biofísica; Argentina.
dc.description.filFil: Bonomo, Robert A. Research Service and GRECC. Louis Stokes Cleveland Department of Veterans Affairs Medical Center; USA.
dc.description.filFil: Bonomo, Robert A. Case Western Reserve University School of Medicine. Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Biochemistry, Proteomics and Bioinformatics; USA.
dc.description.filFil: Bonomo, Robert A. Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; USA.
dc.description.filFil: Ramírez, María Soledad. California State University. College of Natural Sciences and Mathematics. Center for Applied Biotechnology Studies. Department of Biological Science; USA.
dc.description.sponsorshipBiomedical Laboratory Research and Development, VA Office of Research and Development: 1I01BX001974
dc.format.extent1-6
dc.identifier.issn2379-5042
dc.identifier.urihttps://hdl.handle.net/2133/27319
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.relation.publisherversionhttps://doi.org/10.1128/mSphere.00793-20
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/msphere.00793-20
dc.rightsopenAccess
dc.rights.holderHuang, Fanny
dc.rights.holderFitchett, Noelle
dc.rights.holderRazo Gutiérrez, Chelsea
dc.rights.holderLe, Casin
dc.rights.holderMartínez, Jasmine
dc.rights.holderRa, Grace
dc.rights.holderLópez, Carolina
dc.rights.holderGonzález, Lisandro Javier
dc.rights.holderSieira, Rodrigo
dc.rights.holderVila, Alejandro J.
dc.rights.holderBonomo, Robert A.
dc.rights.holderRamírez, María Soledad
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textATTRIBUTION 4.0 INTERNATIONAL CC BY 4.0
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAcinetobacter baumannii
dc.subjectH-NS
dc.subjectStress
dc.subjectCarbapenemases
dc.subjectAcinetobacter
dc.subjectCarbapenems
dc.titleThe H-NS regulator plays a role in the stress induced by carbapenemase expression in acinetobacter baumannii
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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(FBIOyF) Departamento de Bioquímica Clínica - Artículos