Zanthosimuline and Related Pyranoquinolines as Antifungal Agents for Postharvest Fruit Disease Control

Di Liberto, Melina G.; Caldo, Agustín J.; Quiroga, Ariel Darío; Riveira, Martín Jorge; Derita, Marcos G.

Zanthosimuline and Related Pyranoquinolines as Antifungal Agents for Postharvest Fruit Disease Control

dc.citation.title	ACS Omega	es
dc.citation.volume	5	es
dc.creator	Di Liberto, Melina G.
dc.creator	Caldo, Agustín J.
dc.creator	Quiroga, Ariel Darío
dc.creator	Riveira, Martín Jorge
dc.creator	Derita, Marcos G.
dc.date.accessioned	2021-08-26T21:10:05Z
dc.date.available	2021-08-26T21:10:05Z
dc.date.issued	2020
dc.description	The natural product zanthosimuline and its 18 analogues were easily prepared from simple starting materials and evaluated in vitro against postharvest fruit fungal pathogens. The panel included Penicillium digitatum, Botrytis cinerea, Monilinia fructicola, and Rhizopus stolonifer; all of them causing relevant economic losses worldwide. The minimum inhibitory concentrations and minimum fungicidal concentrations of each compound were determined, and the main structure–activity relationships were established. The biological activity observed was strongly increased by maintaining the prenyl side chain of zanthosimuline in an N-demethylated derivative. In addition, the compound that is the most active in the in vitro evaluation was tested in freshly harvested peaches exhibiting a promising brown rot control profile, comparable to the commercial agent carbendazim but demonstrating less toxicity against human liver cell lines.	es
dc.description.fil	Fil: Di Liberto, Melina G. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Farmacognosia; Argentina.	es
dc.description.fil	Fil: Caldo, Agustín J. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.	es
dc.description.fil	Fil: Quiroga, Ariel D. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina.	es
dc.description.fil	Fil: Riveira, Martín Jorge. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.	es
dc.description.fil	Fil: Derita, Marcos G. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Farmacognosia; Argentina.	es
dc.description.fil	Fil: Derita, Marcos G. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias. Instituto de Ciencias Agropecuarias del Litoral (ICiAgro Litoral-CONICET); Argentina.	es
dc.description.sponsorship	Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)	es
dc.description.sponsorship	Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP No 2015-0524	es
dc.description.sponsorship	Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT No 2015-2259	es
dc.description.sponsorship	Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT No 2014-0408	es
dc.description.sponsorship	Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT No 2017-2694	es
dc.description.sponsorship	Agencia Santafesina de Ciencia, Tecnología e Innovación (ASACTEI): AC - 2015-00005	es
dc.description.sponsorship	Universidad Nacional de Rosario (UNR): BIO580	es
dc.format	application/pdf
dc.format.extent	7481–7487	es
dc.identifier.issn	2470-1343	es
dc.identifier.uri	http://hdl.handle.net/2133/21775
dc.language.iso	eng	es
dc.publisher	American Chemical Society	es
dc.relation.publisherversion	https://pubs.acs.org/doi/10.1021/acsomega.0c00225#	es
dc.relation.publisherversion	https://doi.org/10.1021/acsomega.0c00225	es
dc.rights	openAccess	es
dc.rights.holder	Di Liberto, Melina G.	es
dc.rights.holder	Caldo, Agustín J.	es
dc.rights.holder	Quiroga, Ariel D.	es
dc.rights.holder	Riveira, Martín Jorge	es
dc.rights.holder	Derita, Marcos G.	es
dc.rights.text	Atribución-NoComercial-CompartirIgual	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/2.5/ar/	*
dc.subject	Infectious diseases	es
dc.subject	Antimicrobial agents	es
dc.subject	Reaction products	es
dc.subject	Solvents	es
dc.subject	Organic compounds	es
dc.title	Zanthosimuline and Related Pyranoquinolines as Antifungal Agents for Postharvest Fruit Disease Control	es
dc.type	article
dc.type	artículo
dc.type	publishedVersion
dc.type.collection	articulo
dc.type.version	publishedVersion	es