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Characterization of albendazole-randomly methylated-β-cyclodextrin inclusion complex and in vivo evaluation of its antihelmitic activity in a murine model of trichinellosis

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dc.citation.titlePLoS ONE
dc.citation.volume9
dc.creatorGarcía, Agustina
dc.creatorLeonardi, Darío
dc.creatorVasconi, María D.
dc.creatorHinrichsen, Lucila Isabel
dc.creatorLamas, María Celina
dc.date.accessioned2024-07-02T14:20:04Z
dc.date.available2024-07-02T14:20:04Z
dc.date.issued2014-11-18
dc.description.abstractAlbendazole is a benzimidazole carbamate extensively used in oral chemotherapy against intestinal parasites, due to its broad spectrum activity, good tolerance and low cost. However, the drug has the disadvantage of poor bioavailability due to its very low solubility in water; as a consequence, a very active area of research focuses on the development of new pharmaceutical formulations to increase its solubility, dissolution rate, and bioavailability. The primary objective of this study was to prepare randomly methylated β-cyclodextrins inclusion complexes to increase albendazole dissolution rate, in order to enhance its antiparasitic activity. This formulation therapeutic efficacy was contrasted with that of the pure drug by treating Trichinella spiralis infected mice during the intestinal phase of the parasite cycle, on days five and six post-infection. This protocol significantly decreased muscle larval burden measured in the parenteral stage on day 30 post-infection, when compared with the untreated control. Thus, it could be demonstrated that the inclusion complexes improve the in vivo therapeutic activity of albendazole.
dc.description.filFil: García, Agustina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET). Departamento de Farmacia; Argentina.
dc.description.filFil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET). Departamento de Farmacia; Argentina.
dc.description.filFil: Vasconi, María D. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Parasitología; Argentina.
dc.description.filFil: Vasconi, María D. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental; Argentina.
dc.description.filFil: Hinrichsen, Lucila Isabel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental; Argentina.
dc.description.filFil: Lamas, María Celina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET). Departamento de Farmacia; Argentina.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Proyectos de Investigación Plurianuales (PIP): N° 112-201001-00194
dc.description.versionpeerreviewed
dc.format.extent1-7
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/2133/27388
dc.language.isoen
dc.publisherPublic Library of Science (PLOS)
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0113296
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113296
dc.rightsopenAccess
dc.rights.holderGarcía, Agustina
dc.rights.holderLeonardi, Darío
dc.rights.holderVasconi, María D.
dc.rights.holderHinrichsen, Lucila Isabel
dc.rights.holderLamas, María Celina
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAlbendazole
dc.subjectMethylated-β-cyclodextrin
dc.subjectAntihelmitic activity
dc.subjectAntiparasitic agents
dc.subjectTrichinellosis
dc.subjectPharmaceutical preparations
dc.subjectBiological availability
dc.subjectSolubility
dc.subjectDissolution
dc.titleCharacterization of albendazole-randomly methylated-β-cyclodextrin inclusion complex and in vivo evaluation of its antihelmitic activity in a murine model of trichinellosis
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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