Dental pulp is a soft connective tissue type that thanks to its components can fulfill a number of vital functions to the tooth. Within these, the sensory function is of great interest since there is a close relationship between histomolecular tissue changes and clinical manifestations of odontogenic pain. To think about the painful history that the patient reports, knowing the tissue level events, helps to arrive to a correct diagnosis, treatment plan and prognosis.
The aim of this paper is to focus the bibliographic tracking in the series of mechanisms involved in the manifestation of pain. To achieve this it will be necessary to deepen in the sensory nerve fibers of the dental pulp and in the biomolecular processes that take place tounleash the response to the painful stimulus.