Design and characterization of chitosan nanoformulations for the delivery of antifungal agents

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dc.citation.titleInternational Journal of Molecular Scienceses
dc.citation.volume20(15)es
dc.creatorCalvo, Natalia Lorena
dc.creatorSreekumar, Sruthi
dc.creatorSvetaz, Laura
dc.creatorLamas, María Celina
dc.creatorMoerschbacher, Bruno M.
dc.creatorLeonardi, Darío
dc.date.accessioned2021-02-24T19:20:17Z
dc.date.available2021-02-24T19:20:17Z
dc.date.issued2019-07-27
dc.descriptionAmong different Candida species triggering vaginal candidiasis, Candida albicans is the most predominant yeast. It is commonly treated using azole drugs such as Tioconazole (TIO) and Econazole (ECO). However, their low water solubility may affect their therapeutic efficiency. Therefore, the aim of this research was to produce a novel chitosan nanocapsule based delivery system comprising of TIO or ECO and to study their suitability in vaginal application. These systems were characterized by their physicochemical properties, encapsulation efficiency, in vitro release, storage stability, cytotoxicity, and in vitro biological activity. Both nanocapsules loaded with TIO (average hydrodynamic size of 146.8 ± 0.8 nm, zeta potential of +24.7 ± 1.1 mV) or ECO (average hydrodynamic size of 127.1 ± 1.5 nm, zeta potential of +33.0 ± 1.0 mV) showed excellent association efficiency (99% for TIO and 87% for ECO). The analysis of size, polydispersity index, and zeta potential of the systems at 4, 25, and 37 ◦C (over a period of two months) showed the stability of the systems. Finally, the developed nanosystems presented fungicidal activity against C. albicans at non-toxic concentrations (studied on model human skin cells). The results obtained from this study are the first step in the development of a pharmaceutical dosage form suitable for the treatment of vaginal candidiasis.es
dc.descriptionPara citar este articulo: Calvo, N.L.; Sreekumar, S.; Svetaz, L.A.; Lamas, M.C.; Moerschbacher, B.M.; Leonardi, D. Design and Characterization of Chitosan Nanoformulations for the Delivery of Antifungal Agents. Int. J. Mol. Sci. 2019, 20, 3686. https://doi.org/10.3390/ijms20153686
dc.description.filFil: Calvo, Natalia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Calvo, Natalia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Análisis de Medicamentos; Argentina.es
dc.description.filFil: Sreekumar, Sruthi. Westfälische Wilhelms-Universität Münster. Institute for Biology and Biotechnology of Plants (IBBP); Germany.es
dc.description.filFil: Svetaz, Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacognosia; Argentina.es
dc.description.filFil: Lamas, María Celina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Lamas, María Celina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Farmacia. Área Técnica Farmacéutica; Argentina.es
dc.description.filFil: Moerschbacher, Bruno M. Westfälische Wilhelms-Universität Münster. Institute for Biology and Biotechnology of Plants (IBBP); Germany.es
dc.description.filFil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Farmacia. Área Técnica Farmacéutica; Argentina.es
dc.description.sponsorshipOpen Access Publication Fund of the University of Muensteres
dc.formatapplication/pdf
dc.format.extent1-16es
dc.identifier.issn1422-0067es
dc.identifier.urihttp://hdl.handle.net/2133/19686
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://doi.org/10.3390/ijms20153686es
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/20/15/3686es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderCalvo, Natalia Lorenaes
dc.rights.holderSreekumar, Sruthies
dc.rights.holderSvetaz, Lauraes
dc.rights.holderLamas, María Celinaes
dc.rights.holderMoerschbacher, Bruno M.es
dc.rights.holderLeonardi, Daríoes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectChitosan Nanocapsuleses
dc.subjectDrug Delivery Systemses
dc.subjectAntifungal Agentses
dc.subjectBiological Activityes
dc.subjectCandidiasis, Vulvovaginales
dc.subjectEconazolees
dc.subjectTioconazolees
dc.titleDesign and characterization of chitosan nanoformulations for the delivery of antifungal agentses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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