Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs
| dc.citation.title | Natural Product Communications | es |
| dc.citation.volume | 10(9) | es |
| dc.creator | Campos, Adriana | |
| dc.creator | Rodrigues Souza, Greice Maria | |
| dc.creator | Delle Monache, Franco | |
| dc.creator | Butassi, Estefanía | |
| dc.creator | Zacchino, Susana | |
| dc.creator | Cechinel Filho, Valdir | |
| dc.date.accessioned | 2020-12-22T15:19:13Z | |
| dc.date.available | 2020-12-22T15:19:13Z | |
| dc.date.issued | 2015-09-01 | |
| dc.description | Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relevant yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with the microbroth dilution method, following the guidelines of CLSI. Eleutherine, isoeleutherine and eleutherol all presented significant antifungal activity, especially the first two, the major components, with MIC values between 7.8 and 250 µg/mL. In conclusion, these results demonstrate that C. paludosa bulbs produce active principles with relevant antifungal potential, contributing, at least in part, to the antimicrobial effect evidenced for this plant and justifying its popular use against infections. | es |
| dc.description.fil | Fil: Campos, Adriana. Universidade do Vale do Itajaí (UNIVALI). Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR); Brazil. | es |
| dc.description.fil | Fil: Rodrigues Souza, Greice Maria. Centro Universitário Euro-Americano (UNIEURO). Núcleo da Saúde; Brazil. | es |
| dc.description.fil | Fil: Delle Monache, Franco. Universidade do Vale do Itajaí (UNIVALI). Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR); Brazil. | es |
| dc.description.fil | Fil: Butassi, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacognosia; Argentina. | es |
| dc.description.fil | Fil: Zacchino, Susana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacognosia; Argentina. | es |
| dc.description.fil | Fil: Cechinel Filho, Valdir. Universidade do Vale do Itajaí (UNIVALI). Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR); Brazil. | es |
| dc.description.sponsorship | Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 2014- 1170 | es |
| dc.description.sponsorship | Universidad Nacional de Rosario (UNR) | es |
| dc.description.sponsorship | Universidade do Vale do Itajaí (UNIVALI) | es |
| dc.description.sponsorship | Rede Iberoamericana de Estudo e Aproveitamento Sustentável da Biodiversidade Regional de Interesse Farmacêutico (RIBIOFAR)/ Programa Iberoamericano de Ciência y Tecnologia Para el Desarrollo (CYTED) | es |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | es |
| dc.description.sponsorship | Coordenação de aperfeiçoamento de pessoal de nivel superior (CAPES) | es |
| dc.format | application/pdf | |
| dc.format.extent | 1589-1592 | es |
| dc.identifier.issn | 1555-9475 | es |
| dc.identifier.uri | http://hdl.handle.net/2133/19533 | |
| dc.language.iso | eng | es |
| dc.publisher | SAGE | es |
| dc.relation.publisherversion | https://doi.org/10.1177/1934578x1501000926 | es |
| dc.relation.publisherversion | https://journals.sagepub.com/doi/10.1177/1934578X1501000926#articlePermissionsContainer | es |
| dc.rights | openAccess | es |
| dc.rights.holder | Universidad Nacional de Rosario | es |
| dc.rights.holder | SAGE | es |
| dc.rights.holder | Campos, Adriana | es |
| dc.rights.holder | Rodrigues Souza, Greice Maria | es |
| dc.rights.holder | Delle Monache, Franco | es |
| dc.rights.holder | Butassi, Estefanía | es |
| dc.rights.holder | Zacchino, Susana | es |
| dc.rights.holder | Cechinel Filho, Valdir | es |
| dc.rights.text | Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) | es |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.subject | Cipura paludosa | es |
| dc.subject | Antifungal Activity | es |
| dc.subject | Pyranonaphthoquinones | es |
| dc.title | Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs | es |
| dc.type | article | |
| dc.type | artículo | |
| dc.type | publishedVersion | |
| dc.type.collection | articulo | |
| dc.type.version | publishedVersion | es |