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First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct

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dc.citation.titleHistochemistry and Cell Biologyes
dc.citation.volume141(2)es
dc.creatorRoldán, María Lorena
dc.creatorMarini, Patricia Estela
dc.date.accessioned2019-02-13T23:04:29Z
dc.date.available2019-02-13T23:04:29Z
dc.date.issued2014-02
dc.descriptionThe oviduct supports the transport and final maturation of gametes, and harbors fertilization and early embryo development. The oviductal epithelium is responsible for providing the correct environment for these processes. Deleted in malignant brain tumor 1 (DMBT1) is expressed by multiple organisms and several cell types, and the interaction of the rabbit ortholog of DMBT1 with galectin-3 (gal-3) modulates the polarity of epithelial cells. This interaction has not yet been shown in locations other than rabbit kidney and human-cultured endothelial cells. DMBT1 and gal-3 also protect epithelial layers from pathogens and trauma, and are innate immunity components. DMBT1 has been detected in the porcine oviduct, and gal-3 has been reported in the Fallopian tube and in the cow oviduct. Interaction between both proteins would show a probable physiological function in the female reproductive tract. This work describes the presence and co-localization of DMBT1 and gal-3 mainly in the apical region of the epithelial cells of the Fallopian tube and the porcine oviduct, and co-immunoprecipitation in membrane-enriched epithelial cell extracts from the porcine oviduct. The findings strongly support a functional interaction in the mammalian oviduct, suggestive of a role on epithelial protection and homeostasis, which might be related to epithelium–gamete interaction.es
dc.description.filFil: Roldán, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Marini, Patricia Estela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): BID Program, Grant number PICT 1284-2007es
dc.description.sponsorshipSanta Fe (Argentina : Provincia). Secretaría de Estado de Ciencia, Tecnología e Innovación Productiva (SECTeI): Grant 21010-098-12es
dc.formatapplication/pdf
dc.format.extent181-190es
dc.identifier.issn0948-6143es
dc.identifier.urihttp://hdl.handle.net/2133/13972
dc.language.isoenges
dc.publisherSpringeres
dc.relation.publisherversionhttp://dx.doi.org/10.1007/s00418-013-1145-2es
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs00418-013-1145-2es
dc.rightsopenAccesses
dc.rights.holderRoldán, María Lorenaes
dc.rights.holderMarini, Patricia Estelaes
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticases
dc.rights.holderSpringeres
dc.rights.textAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)es
dc.rights.uri*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es*
dc.subjectOviductes
dc.subjectFallopian tubees
dc.subjectDMBT1es
dc.subjectGalectin-3es
dc.titleFirst evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviductes
dc.typearticle
dc.typeartículo
dc.typeacceptedVersion
dc.type.collectionarticulo
dc.type.versionacceptedVersiones

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