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The urgent need for metallo-β-lactamase inhibitors: an unattended global threat

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dc.citation.titleThe Lancet Infectious Diseaseses
dc.citation.volume22
dc.creatorMojica, Maria F.
dc.creatorRossi, María Agustina
dc.creatorVila, Alejandro J.
dc.creatorBonomo, Robert A.
dc.date.accessioned2022-04-08T17:13:33Z
dc.date.available2022-04-08T17:13:33Z
dc.date.issued2021-07-08
dc.descriptionDue to their superior tolerability and efficacy, β-lactams are the most potent and prescribed class of antibiotics in the clinic. The emergence of resistance to those antibiotics, mainly due to the production of bacterial enzymes called β-lactamases, has been partially solved by the introduction of β-lactamase inhibitors, which restore the activity of otherwise obsolete molecules. This solution is limited because currently available β-lactamase inhibitors only work against serine β-lactamases, whereas metallo-β-lactamases continue to spread, evolve, and confer resistance to all β-lactams, including carbapenems. Furthermore, the increased use of antibiotics to treat secondary bacterial pneumonia in severely sick patients with COVID-19 might exacerbate the problem of antimicrobial resistance. In this Personal View, we summarise the main advances accomplished in this area of research, emphasise the main challenges that need to be solved, and the importance of research on inhibitors for metallo-B-lactamases amidst the current pandemic.es
dc.description.filFil: Mojica, Maria F. Case Western Reserve University. School of Medicine. Infectious Diseases Department; United States.es
dc.description.filFil: Mojica, Maria F. Veterans Affairs Northeast Ohio Healthcare System. Research Service; United States.es
dc.description.filFil: Mojica, Maria F. Universidad El Bosque. Grupo de Resistencia Antimicrobiana y Epidemiología Hospitalaria; Colombia.es
dc.description.filFil: Rossi, María Agustina. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Vila, Alejandro J. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Vila, Alejandro J. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Biofísica; Argentina.es
dc.description.filFil: Vila, Alejandro J. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; United States.es
dc.description.filFil: Bonomo, Robert A. Veterans Affairs Northeast Ohio Healthcare System. Research Service; United States.es
dc.description.filFil: Bonomo, Robert A. Case Western Reserve University School of Medicine. Department of Medicine, Department of Pharmacology, Department of Molecular Biology and Microbiology, Department of Biochemistry. Case Center for Proteomics and Bioinformatics; United States.es
dc.description.filFil: Bonomo, Robert A. Veterans Affairs Northeast Ohio Healthcare System. Medical Service and Geriatric Research Education and Clinical Center; United States.es
dc.description.filFil: Bonomo, Robert A. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; United States.es
dc.description.sponsorshipCleveland Department of Veterans Affairs: 1I01BX001974
dc.description.sponsorshipNational Institutes of Health (NIH): R01AI100560
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID)
dc.description.sponsorshipBiomedical Laboratory Research and Development, VA Office of Research and Development
dc.description.sponsorshipGeriatric Research Education and Clinical Center
dc.formatapplication/pdf
dc.format.extente28-e34es
dc.identifier.issn1474-4457es
dc.identifier.urihttp://hdl.handle.net/2133/23377
dc.language.isoenges
dc.publisherElsevier Ltdes
dc.relation.publisherversionhttps://doi.org/10.1016/S1473-3099(20)30868-9
dc.rightsopenAccesses
dc.rights.holderElsevier Ltdes
dc.rights.textAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnti-bacterial agentses
dc.subjectBeta-lactamase inhibitorses
dc.subjectDrug resistancees
dc.subjectBeta-lactamses
dc.subjectCoinfectiones
dc.subjectBacteriales
dc.subjectGlobal healthes
dc.titleThe urgent need for metallo-β-lactamase inhibitors: an unattended global threates
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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