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Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders

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dc.citation.titleFrontiers in Endocrinologyes
dc.citation.volume6es
dc.creatorRodríguez, Amaia
dc.creatorMarinelli, Raúl A.
dc.creatorTesse, Angela
dc.creatorFrühbeck, Gema
dc.creatorCalamita, Giuseppe
dc.date.accessioned2021-03-01T16:21:39Z
dc.date.available2021-03-01T16:21:39Z
dc.date.issued2015-11-05
dc.descriptionGender differences in the relative risk of developing metabolic complications, such as insulin resistance or non-alcoholic fatty liver disease (NAFLD), have been reported. The deregulation of glycerol metabolism partly contributes to the onset of these metabolic diseases, since glycerol constitutes a key substrate for the synthesis of triacylglycerols (TAGs) as well as for hepatic gluconeogenesis. The present mini-review covers the sexrelated differences in glycerol metabolism and aquaglyceroporins (AQPs) and its impact in the control of adipose and hepatic fat accumulation as well as in whole-body glucose homeostasis. Plasma glycerol concentrations are increased in women compared to men probably due to the higher lipolytic rate and larger AQP7 amounts in visceral fat as well as the well-known sexual dimorphism in fat mass with women showing higher adiposity. AQP9 represents the primary route for glycerol uptake in hepatocytes, where glycerol is converted by the glycerol-kinase enzyme into glycerol-3-phosphate, a key substrate for de novo synthesis of glucose and TAG. In spite of showing similar hepatic AQP9 protein, women exhibit lower hepatocyte glycerol permeability than men, which might contribute to their lower prevalence of insulin resistance and NAFLD.es
dc.descriptionPara citar este articulo: Rodríguez A, Marinelli RA, Tesse A, Frühbeck G and Calamita G (2015) Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in Health and Metabolic Disorders. Front. Endocrinol. 6:171. doi: 10.3389/fendo.2015.00171
dc.description.filFil: Rodríguez, Amaia. Laboratorio de Investigación Metabólica, Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Clínica Universidad de Navarra; España.es
dc.description.filFil: Marinelli, Raúl A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE -CONICET); Argentina.es
dc.description.filFil: Tesse, Angela. l'Université de Nantes. Institut de Recherche en Santé de l'Université de Nantes (IRS-UN); France.es
dc.description.filFil: Tesse, Angela. Institut national de la santé et de la recherche médicale (INSERM); France.es
dc.description.filFil: Tesse, Angela. Centre national de la recherche scientifique (CNRS); France.es
dc.description.filFil: Tesse, Angela. Institut du Thorax; France.es
dc.description.filFil: Frühbeck, Gema. Laboratorio de Investigación Metabólica, Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Clínica Universidad de Navarra; España.es
dc.description.filFil: Calamita, Giuseppe. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharmaceutics; Italy.es
dc.description.sponsorshipRegione Puglia (Rete di Laboratori Pubblici di Ricerca “WAFITECH”)es
dc.description.sponsorshipFondazione Cassa di Risparmio di Puglia (Ricerca Scientifica e Tecnologica)es
dc.description.sponsorshipMinistero dell’Istruzione, dell’Università e della Ricerca (MIUR): PRIN20089SRS2X_003es
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII). Fondo de Investigación Sanitaria FEDER: PI12/00515 y PI13/01430es
dc.description.sponsorshipDepartment of Health of the Gobierno de Navarra: 61/2014es
dc.description.sponsorshipPlan de Investigación de la Universidad de Navarra: PIUNA 2011-14es
dc.formatapplication/pdf
dc.format.extent1-7es
dc.identifier.issn1664-2392es
dc.identifier.urihttp://hdl.handle.net/2133/19956
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.relation.publisherversionhttps://doi.org/10.3389/fendo.2015.00171es
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fendo.2015.00171/fulles
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderRodríguez, Amaiaes
dc.rights.holderMarinelli, Raúl A.es
dc.rights.holderTesse, Angelaes
dc.rights.holderFrühbeck, Gemaes
dc.rights.holderCalamita, Giuseppees
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectGlyceroles
dc.subjectMetabolismes
dc.subjectAquaglyceroporinses
dc.subjectObesityes
dc.subjectInsulin Resistancees
dc.subjectFatty Liver Disease (NAFLD)es
dc.subjectGender Dimorphismes
dc.titleSexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorderses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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