A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
| dc.citation.title | Molecules | es |
| dc.citation.volume | 22(7) | es |
| dc.creator | Li, Chun-shun | |
| dc.creator | Sarotti, Ariel Marcelo | |
| dc.creator | Yang, Baojun | |
| dc.creator | Turkson, James | |
| dc.creator | Cao, Shugeng | |
| dc.date.accessioned | 2020-12-22T14:51:11Z | |
| dc.date.available | 2020-12-22T14:51:11Z | |
| dc.date.issued | 2017-07-12 | |
| dc.description | A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1) by extensive spectroscopic analysis and comparison with the literature. The absolute configuration of 1 was determined by comparison with the experimental and calculated ECD spectra. The absolute configuration of compound 3 was investigated and renamed as (+)-epipyridone by comparison of the optical rotation and CD spectrum with those of 1. The other known compounds were identified as epicoccarine B (2), D8646-2-6 (4), and iso-D8646-2-6 (5). Compounds 4 and 5 showed modest inhibitory activity towards pathogenic fungi. Epicoccarine B (2) inhibited A2780 and TK-10 with an IC50 value of 22 µM. | es |
| dc.description | Para citar este articulo: Li, C.; Sarotti, A.M.; Yang, B.; Turkson, J.; Cao, S. A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. Molecules 2017, 22, 1166. | |
| dc.description.fil | Fil: Li, Chun-shun. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. | es |
| dc.description.fil | Fil: Li, Chun-shun. University of Hawaii Cancer Center. Cancer Biology Program; United States. | es |
| dc.description.fil | Fil: Sarotti, Ariel Marcelo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. | es |
| dc.description.fil | Fil: Yang, Baojun. University of Hawaii Cancer Center. Cancer Biology Program; United States. | es |
| dc.description.fil | Fil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; United States. | es |
| dc.description.fil | Fil: Cao, Shugeng. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. | es |
| dc.description.fil | Fil: Cao, Shugeng. University of Hawaii Cancer Center. Cancer Biology Program; United States. | es |
| dc.description.sponsorship | University of Hawaii Cancer Center | es |
| dc.description.sponsorship | University of Hawaii at Hilo | es |
| dc.description.sponsorship | Victoria S. and Bradley L. Geist Foundation: 15ADVC-74420 and 17CON-86295 | es |
| dc.description.sponsorship | National Institutes of Health (NIH)/National Cancer Institute (NCI): Grant CA128865 | es |
| dc.format | application/pdf | |
| dc.format.extent | 1-8 | es |
| dc.identifier.issn | 1420-3049 | es |
| dc.identifier.uri | http://hdl.handle.net/2133/19532 | |
| dc.language.iso | eng | es |
| dc.publisher | MDPI | es |
| dc.relation.publisherversion | https://doi.org/10.3390/molecules22071166 | es |
| dc.relation.publisherversion | https://www.mdpi.com/1420-3049/22/7/1166 | es |
| dc.rights | openAccess | es |
| dc.rights.holder | Universidad Nacional de Rosario | es |
| dc.rights.holder | Li, Chunshun | es |
| dc.rights.holder | Sarotti, Ariel Marcelo | es |
| dc.rights.holder | Yang, Baojun | es |
| dc.rights.holder | Turkson, James | es |
| dc.rights.holder | Cao, Shugeng | es |
| dc.rights.text | Attribution 4.0 International (CC BY 4.0) | es |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Endophytic Fungi | es |
| dc.subject | Coculture Techniques | es |
| dc.subject | Pyridones | es |
| dc.subject | Tetramic Acid | es |
| dc.subject | Hawaii | es |
| dc.title | A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062 | es |
| dc.type | article | |
| dc.type | artículo | |
| dc.type | publishedVersion | |
| dc.type.collection | articulo | |
| dc.type.version | publishedVersion | es |