Gold-catalyzed addition of β-ketoesters to alkenes: influence of electronic and steric effects in the reaction outcome
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Date
2018-03-10
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Publisher
MDPI
Abstract
Description
The gold-catalyzed intermolecular hydroalkylation of olefins with β-ketoesters represents
a conceptually attractive and useful synthetic tool; however, it has been scarcely applied, remaining
a challenge for chemists. The aim of the current study was to investigate the addition of these
1,3-diketo-compounds to alkenes under gold catalysis conditions, in order to establish the electronic
and steric effects of the alkenyl substrates in the reaction outcome. The screening of different catalyst
systems and diverse olefins enabled defining the alkenyl requirements and the best reaction conditions
to efficiently achieve the coupled products.
Para citar este articulo: La-Venia, A.; Mischne, M.P.; Mata, E.G. Gold-Catalyzed Addition of β-Ketoesters to Alkenes: Influence of Electronic and Steric Effects in the Reaction Outcome. Molecules 2018, 23, 629.
Para citar este articulo: La-Venia, A.; Mischne, M.P.; Mata, E.G. Gold-Catalyzed Addition of β-Ketoesters to Alkenes: Influence of Electronic and Steric Effects in the Reaction Outcome. Molecules 2018, 23, 629.
Keywords
Catalysis, Gold, Hydroalkylation, beta-Ketoesters, Alkenes