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Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway

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dc.citation.titleScientific Reportses
dc.citation.volume9es
dc.creatorSimão-Gurge, Raquel M.
dc.creatorWunderlich, Gerhard
dc.creatorCricco, Julia Alejandra
dc.creatorGalindo Cubillos, Eliana F.
dc.creatorDomenech-Carbó, Antonio
dc.creatorCebrián-Torrejón, Gerardo
dc.creatorAlmeida, Fernando G.
dc.creatorCirulli, Brenda Analía
dc.creatorKatzin, Alejandro M.
dc.date.accessioned2020-06-08T19:36:02Z
dc.date.available2020-06-08T19:36:02Z
dc.date.issued2019-12-17
dc.descriptionA number of antimalarial drugs interfere with the electron transport chain and heme-related reactions; however, the biosynthesis of heme derivatives in Plasmodium parasites has not been fully elucidated. Here, we characterized the steps that lead to the farnesylation of heme. After the identification of a gene encoding heme O synthase, we identified heme O synthesis in blood stage parasites through the incorporation of radioactive precursors. The presence of heme O synthesis in intraerythrocytic stages of Plasmodium falciparum was confirmed by mass spectrometry. Inabenfide and uniconazole–P appeared to interfere in heme synthesis, accordingly, parasite growth was also affected by the addition of these drugs. We conclude that heme O synthesis occurs in blood stage-P. falciparum and this pathway could be a potential target for antimalarial drugs.es
dc.description.filFil: Simão-Gurge, Raquel M. University of São Paulo. Institute of Biomedical Sciences. Department of Parasitology; Braziles
dc.description.filFil: Wunderlich, Gerhard. University of São Paulo. Institute of Biomedical Sciences. Department of Parasitology; Braziles
dc.description.filFil: Cricco, Julia Alejandra. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Biológica. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Galindo Cubillos, Eliana F. University of São Paulo. Institute of Biomedical Sciences. Department of Parasitology; Braziles
dc.description.filFil: Domenech-Carbó, Antonio. University of Valencia. Faculty of Chemistry. Department of Analytical Chemistry; Spaines
dc.description.filFil: Cebrián-Torrejón, Gerardo. University of Valencia. Faculty of Chemistry. Department of Analytical Chemistry; Spaines
dc.description.filFil: Cebrián-Torrejón, Gerardo. Université des Antilles. Laboratoire COVACHIM-M2E EA 3592; Francees
dc.description.filFil: Almeida, Fernando G. University of São Paulo. Institute of Biomedical Sciences. Department of Parasitology; Braziles
dc.description.filFil: Cirulli, Brenda Analía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Biológica. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Katzin, Alejandro M. University of São Paulo. Institute of Biomedical Sciences. Department of Parasitology; Braziles
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)es
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)es
dc.formatapplication/pdf
dc.format.extent19261es
dc.identifier.issn2045-2322es
dc.identifier.urihttp://hdl.handle.net/2133/18326
dc.language.isoenges
dc.publisherSpringer Naturees
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-55506-yes
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-019-55506-yes
dc.rightsopenAccesses
dc.rights.holderSimão-Gurge, Raquel M.es
dc.rights.holderWunderlich, Gerhardes
dc.rights.holderCricco, Julia Alejandraes
dc.rights.holderGalindo Cubillos, Eliana F.es
dc.rights.holderDomenech-Carbó, Antonioes
dc.rights.holderCebrián-Torrejón, Gerardoes
dc.rights.holderAlmeida, Fernando G.es
dc.rights.holderCirulli, Brenda Analíaes
dc.rights.holderKatzin, Alejandro M.es
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAntimalarial drugses
dc.subjectPlasmodium parasiteses
dc.subjectHeme O synthesises
dc.subjectPlasmodium Falciparumes
dc.subjectInhibitorses
dc.titleBiosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathwayes
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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