Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field
| dc.citation.title | Cancer Investigation | es |
| dc.citation.volume | 32 | es |
| dc.creator | Rico, María José | |
| dc.creator | Perroud, Herman A | |
| dc.creator | Mainetti, Leandro Ernesto | |
| dc.creator | Rozados, Viviana R. | |
| dc.creator | Scharovsky, O. Graciela | |
| dc.date.accessioned | 2018-04-19T17:01:01Z | |
| dc.date.available | 2018-04-19T17:01:01Z | |
| dc.date.issued | 2014-02-05 | |
| dc.description | Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic. | es |
| dc.description.fil | Fil: Rico, María José. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina | es |
| dc.description.fil | Fil: Perroud, Herman A. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina | es |
| dc.description.fil | Fil: Mainetti, Leandro Ernesto. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Argentina | es |
| dc.description.fil | Fil: Rozados, Viviana R. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina | es |
| dc.description.fil | Fil: Scharovsky, Graciela Olga. Universidad Nacional de Rosario. Consejo de Investigaciones UNR, Facultad de Ciencias Médicas; Argentina | es |
| dc.description.sponsorship | Universidad Nacional de Rosario | es |
| dc.format | application/pdf | |
| dc.format.extent | 92-98 | es |
| dc.identifier.issn | 0735-7907 | es |
| dc.identifier.uri | http://hdl.handle.net/2133/11113 | |
| dc.language.iso | eng | es |
| dc.publisher | Taylor & Francis | es |
| dc.relation.publisherversion | https://doi.org/10.3109/07357907.2013.877480 | es |
| dc.rights | openAccess | es |
| dc.rights.holder | Autores | es |
| dc.rights.holder | Taylor & Francis | es |
| dc.subject | Metronomic chemotherapy | es |
| dc.subject | Combined treatment | es |
| dc.subject | Cyclophosphamide | es |
| dc.subject | Doxorubicin | es |
| dc.subject | Celecoxib | es |
| dc.subject | Mammary adenocarcinomas | es |
| dc.title | Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field | es |
| dc.type | article | |
| dc.type | artículo | |
| dc.type | acceptedVersion | |
| dc.type.collection | articulo | |
| dc.type.version | acceptedVersion | es |