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Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids

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dc.citation.titleCurrent Medicinal Chemistry
dc.creatorMartínez Peralta, Gonzálo
dc.creatorSerra, Esteban Carlos
dc.creatorAlonso, Victoria Lucía
dc.date.accessioned2023-02-06T12:53:01Z
dc.date.available2023-02-06T12:53:01Z
dc.descriptionThe number of acetylated proteins identified from bacteria to mammals has grown exponentially in the last ten years and it is now accepted that acetylation is a key component in most eukaryotic signaling pathways, as important as phosphorylation. The enzymes involved in this process are well described in mammals; acetyltransferases and deacetylases are found inside and outside the nuclear compartment and have different regulatory functions. In trypanosomatids several of these enzymes have been described and are postulated to be novel antiparasitic targets for the rational design of drugs. In this review article we present an update of the most important known acetylated proteins in trypanosomatids analyzing the acetylomes available. Also, we summarize the information available regarding acetyltransferases and deacetylases in trypanosomes and their potential use as chemotherapeutic targets.es
dc.description"The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/openurl/content.php?genre=article&doi=insert. DOI http://dx.doi.org/10.2174/0929867328666211126145721"
dc.description.filFil: Martínez Peralta, Gonzálo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Serra, Esteban Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Alonso, Victoria Lucía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Martinez Peralta, Gonzalo. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.filFil: Serra, Esteban Carlos. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.filFil: Alonso, Victoria Lucía. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica, Ministerio de Ciencia, Tecnología e Innovación Productiva: PICT 2017–1978, PICT2019-0526
dc.description.sponsorshipUniversidad Nacional de Rosario: PIP1BIO490
dc.formatapplication/pdf
dc.format.extent1-22
dc.identifier.issn1875-533X
dc.identifier.urihttp://hdl.handle.net/2133/25132
dc.language.isoenges
dc.publisherBentham Science Publisherses
dc.relation.publisherversionhttp://dx.doi.org/10.2174/0929867328666211126145721
dc.rightscon embargoes
dc.rights.holderMartínez Peralta, Gonzáloes
dc.rights.holderSerra, Esteban Carloses
dc.rights.holderAlonso, Victoria Lucíaes
dc.rights.textAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)es
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/*
dc.subjectAcetylationes
dc.subjectAcetyltransferaseses
dc.subjectDeacetylaseses
dc.subjectAcetylomees
dc.subjectTrypanosomatidses
dc.subjectCytoskeletones
dc.titleUpdate on the biological relevance of lysine acetylation as a novel drug target in trypanosomatidses
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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