New alkaloids from a hawaiian fungal strain Aspergillus felis FM324
| dc.citation.title | Frontiers in Chemistry | es |
| dc.citation.volume | 9 | |
| dc.creator | Wang, Cong | |
| dc.creator | Sarotti, Ariel Marcelo | |
| dc.creator | Uz Zaman, Ahammad | |
| dc.creator | Wu, Xiaohua | |
| dc.creator | Cao, Shugeng | |
| dc.date.accessioned | 2022-03-28T16:05:45Z | |
| dc.date.available | 2022-03-28T16:05:45Z | |
| dc.date.issued | 2021-08-09 | |
| dc.description | Two new alkaloids tryptoquivaline Y (1) and pseurotin I (2), together with eight known compounds (3–10), were purified from a fungal strain Aspergillus felis FM324, which was isolated from a Hawaiian beach soil sample. The absolute configuration and physicochemical data of tryptoquivaline Z (3) were reported for the first time here in this paper. Compound 1 is an uncommon tryptoquivaline analog containing a 3-Oisobutanoyl group. The structures of the new compounds 1–2 and known compound 3 were elucidated through HRESIMS, NMR spectroscopy and ECD analysis. All the compounds were evaluated for their antiproliferative, antibacterial and NF-κB inhibitory activities. Compound 4 showed weak antibacterial activity against Staphylococcus aureus, methicillin resistant Staphylococcus aureus and Bacillus subtilis with the same MIC value of 59.2 µM. Compounds 3 and 2 inhibited NF-κB with IC50 values of 26.7 and 30.9 μM, respectively. | es |
| dc.description.fil | Fil: Wang, Cong. University of Hawaiʻi at Hilo. Daniel K. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. | es |
| dc.description.fil | Fil: Wang, Cong. Guangxi University for Nationalities. School of Chemistry and Chemical Engineering. Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products. Guangxi Key Laboratory of Chemistry and Engineering of Forest Products. State Ethnic Affairs Commission. Key Laboratory of Chemistry and Engineering of Forest Products; China. | es |
| dc.description.fil | Fil: Sarotti, Ariel Marcelo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina | es |
| dc.description.fil | Fil: Uz Zaman, Ahammad. University of Hawaiʻi at Hilo. Daniel K. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. | es |
| dc.description.fil | Fil: Wu, Xiaohua. University of Hawaiʻi at Hilo. Daniel K. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. | es |
| dc.description.fil | Fil: Cao, Shugeng. University of Hawaiʻi at Hilo. Daniel K. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. | es |
| dc.description.sponsorship | Guangxi for research bases and talents: AD20297036 | |
| dc.description.sponsorship | Guangxi Natural Science Foundation: 2019GXNSFBA185002 | |
| dc.description.sponsorship | University of Hawaii Cancer Center (UHCC) | |
| dc.description.sponsorship | Daniel K. Inouye College of Pharmacy (DKICP) | |
| dc.description.sponsorship | Hawaii IDeA Network for Biomedical Research Excellence III and IV (INBRE-III and INBRE-IV): 5P20GM103466 | |
| dc.format | application/pdf | |
| dc.format.extent | 1-8 | es |
| dc.identifier.issn | 2296-2646 | es |
| dc.identifier.uri | http://hdl.handle.net/2133/23266 | |
| dc.language.iso | eng | es |
| dc.publisher | Frontiers Media | es |
| dc.relation.publisherversion | https://doi.org/10.3389/fchem.2021.724617 | |
| dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fchem.2021.724617/full | |
| dc.rights | openAccess | es |
| dc.rights.holder | Wang, Cong | es |
| dc.rights.holder | Sarotti, Ariel Marcelo | es |
| dc.rights.holder | Uz Zaman, Ahammad | es |
| dc.rights.holder | Wu, Xiaohua | es |
| dc.rights.holder | Cao, Shugeng | es |
| dc.rights.text | Attribution 4.0 International (CC BY 4.0) | es |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Aspergillus felis | es |
| dc.subject | Trichocomaceae | es |
| dc.subject | Alkaloids | es |
| dc.subject | Antiproliferative | es |
| dc.subject | Antibacterial | es |
| dc.subject | NF-κB inhibitory activities | es |
| dc.title | New alkaloids from a hawaiian fungal strain Aspergillus felis FM324 | es |
| dc.type | publishedVersion | |
| dc.type | article | |
| dc.type | artículo | |
| dc.type.collection | articulo | |
| dc.type.version | publishedVersion |