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A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period

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dc.citation.titlePLOS ONEes
dc.creatorParodi, Roberto Leandro
dc.creatorLagrutta, Mariana
dc.creatorTortolo, Mauro
dc.creatorNavall, Estefanía
dc.creatorRodríguez, María S.
dc.creatorSasia, Gervasio Flavio
dc.creatorde Candia, Lucas F.
dc.creatorGruvman, Matias A.
dc.creatorBottasso, Oscar
dc.creatorGreca, Alcides Alejandro
dc.date.accessioned2021-02-26T13:16:08Z
dc.date.available2021-02-26T13:16:08Z
dc.date.issued2019-10-31
dc.descriptionFor better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk according to MASCC criteria, and 53.6% of patients were already hospitalized at the onset of febrile neutropenia. Bloodstream infections were detected in 14% episodes; whereas an infectious source of fever was identified in 80% of cases. Mortality rate achieved to 14.95%. The binary regression analysis showed that persistence of fever at day 7, or neutropenia at day 14, dehydration and tachycardia at the onset of febrile neutropenia as well as prior infections were significantly associated with mortality. In addition to expanding our current knowledge on the features of adult patients with febrile neutropenia, present findings provide useful information for better management of them in Argentina, given the appropriate representativeness of centers participating in the study.es
dc.description.filFil: Parodi, Roberto Leandro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentinaes
dc.description.filFil: Lagrutta, Mariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentinaes
dc.description.filFil: Tortolo, Mauro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentinaes
dc.description.filFil: Navall, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentinaes
dc.description.filFil: Rodríguez, María S. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentinaes
dc.description.filFil: Sasia, Gervasio F. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentinaes
dc.description.filFil: de Candia, Lucas F. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentinaes
dc.description.filFil: Gruvman, Matias A. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentinaes
dc.description.filFil: Bottasso, Oscar. Universidad Nacional de Rosario. Facultad de Ciencias Medicas. Rosario; Argentinaes
dc.description.filFil: Greca, Alcides Alejandro. Universidad Nacional de Rosario. Facultad de Ciencias Medicas. Rosario; Argentinaes
dc.formatapplication/pdf
dc.format.extent1-15es
dc.identifier.issn1932-6203es
dc.identifier.urihttp://hdl.handle.net/2133/19941
dc.language.isoenges
dc.publisherPLOSes
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0224299es
dc.rightsopenAccesses
dc.rights.holder© 2019 Parodi et al.es
dc.rights.texthttps://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectFebrile Neutropeniaes
dc.subjectLongitudinal Studieses
dc.subjectAnti-Bacterial Agentses
dc.subjectProspective Studieses
dc.subjectHematologic Neoplasmses
dc.subjectFeberes
dc.titleA multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year periodes
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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FCM - Instituto de Inmunología - Artículos de Investigación
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