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Conservation of zebrafish microrna-145 and its role during neural crest cell development

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dc.citation.titleGeneses
dc.citation.volume12es
dc.creatorSteeman, Tomás José
dc.creatorRubiolo, Juan Andrés
dc.creatorSánchez, Laura E.
dc.creatorCalcaterra, Nora B.
dc.creatorWeiner, Andrea María Julia
dc.date.accessioned2022-03-28T20:02:35Z
dc.date.available2022-03-28T20:02:35Z
dc.date.issued2021
dc.descriptionThe neural crest is a multipotent cell population that develops from the dorsal neural fold of vertebrate embryos in order to migrate extensively and differentiate into a variety of tissues. A number of gene regulatory networks coordinating neural crest cell specification and differentiation have been extensively studied to date. Although several publications suggest a common role for microRNA-145 (miR-145) in molecular reprogramming for cell cycle regulation and/or cellular differ entiation, little is known about its role during in vivo cranial neural crest development. By modifying miR-145 levels in zebrafish embryos, abnormal craniofacial development and aberrant pigmentation phenotypes were detected. By whole-mount in situ hybridization, changes in expression patterns of col2a1a and Sry-related HMG box (Sox) transcription factors sox9a and sox9b were observed in overexpressed miR-145 embryos. In agreement, zebrafish sox9b expression was downregulated by miR-145 overexpression. In silico and in vivo analysis of the sox9b 3 0UTR revealed a conserved potential miR-145 binding site likely involved in its post-transcriptional regulation. Based on these findings, we speculate that miR-145 participates in the gene regulatory network governing zebrafish chondrocyte differentiation by controlling sox9b expression.es
dc.description.filFil: Steeman, Tomás José. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Argentina.es
dc.description.filFil: Rubiolo, Juan Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Argentina.es
dc.description.filFil: Sánchez, Laura E. Universidade de Santiago de Compostela. Facultad de Veterinaria. Departamento de Zoología Genética y Antropología Física.es
dc.description.filFil: Calcaterra, Nora B. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Argentina.es
dc.description.filFil: Weiner, Andrea María Julia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Argentina.es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT-2017-0507, PICT-2017-0509, PIP-2015-0719
dc.formatapplication/pdf
dc.format.extent1-21es
dc.identifier.issn2073-4425es
dc.identifier.urihttp://hdl.handle.net/2133/23272
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://www.mdpi.com/2073-4425/12/7/1023es
dc.relation.publisherversionhttps://doi.org/10.3390/genes12071023
dc.rightsopenAccesses
dc.rights.holderSteeman, Tomás Josées
dc.rights.holderRubiolo, Juan Andréses
dc.rights.holderSánchez, Laura E.es
dc.rights.holderCalcaterra, Nora B.es
dc.rights.holderWeiner, Andrea María Julia.es
dc.rights.textAtribución 4.0 Internacional (CC BY 4.0)es
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/ar/*
dc.subjectMicroRNAes
dc.subjectNeural Crestes
dc.subjectGene Regulatory Networkes
dc.subjectEmbryonic Developmenes
dc.titleConservation of zebrafish microrna-145 and its role during neural crest cell developmentes
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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