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An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431

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dc.citation.titleMoleculeses
dc.citation.volume24(1)es
dc.creatorLi, Chun-shun
dc.creatorSarotti, Ariel Marcelo
dc.creatorWu, Xiaohua
dc.creatorYang, Baojun
dc.creatorTurkson, James
dc.creatorChen, Yongfei
dc.creatorLiu, Qingsong
dc.creatorCao, Shugeng
dc.date.accessioned2020-12-17T20:24:00Z
dc.date.available2020-12-17T20:24:00Z
dc.date.issued2019-01-07
dc.descriptionA new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 µM.es
dc.descriptionPara citar este articulo: Li, C.; Sarotti, A.M.; Wu, X.; Yang, B.; Turkson, J.; Chen, Y.; Liu, Q.; Cao, S. An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431. Molecules 2019, 24, 196.
dc.description.filFil: Li, Chun-shun. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Li, Chun-shun. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.filFil: Sarotti, Ariel Marcelo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Wu, Xiaohua. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Yang, Baojun. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.filFil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.filFil: Chen, Yongfei. Chinese Academy of Sciences. Hefei Institute of Physical Science. Key Laboratory of High Magnetic Field and Ion Beam Physical Biology. High Magnetic Field Laboratory; China.es
dc.description.filFil: Liu, Qingsong. Chinese Academy of Sciences. Hefei Institute of Physical Science. Key Laboratory of High Magnetic Field and Ion Beam Physical Biology. High Magnetic Field Laboratory; China.es
dc.description.filFil: Cao, Shugeng. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Cao, Shugeng. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.sponsorshipUniversity of Hawaii Cancer Center (SC)es
dc.description.sponsorshipUniversity of Hawai’i at Hilo (SC)es
dc.description.sponsorshipVictoria S. and Bradley L. Geist Foundation: 15ADVC-74420 and 17CON-86295es
dc.description.sponsorshipNational Institutes of Health (NIH). National Cancer Institute (NCI): grant CA128865 (JT)es
dc.formatapplication/pdf
dc.format.extent1-11es
dc.identifier.issn1420-3049es
dc.identifier.urihttp://hdl.handle.net/2133/19504
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://doi.org/10.3390/molecules24010196es
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/24/1/196es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderLi, Chunshunes
dc.rights.holderSarotti, Ariel Marceloes
dc.rights.holderWu, Xiaohuaes
dc.rights.holderYang, Baojunes
dc.rights.holderTurkson, Jameses
dc.rights.holderChen, Yongfeies
dc.rights.holderLiu, Qingsonges
dc.rights.holderCao, Shugenges
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectEndophytic Fungies
dc.subjectPeyronellaeaes
dc.subjectBenzoisoquinoline-9-onees
dc.subjectAntiproliferative Activityes
dc.subjectHawaiies
dc.titleAn unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431es
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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