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The lambda variant in Argentina: analyzing the evolution and spread of SARS-CoV-2 lineage C.37

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dc.citation.titleViruses
dc.citation.volume15
dc.creatorNabaes Jodar, Mercedes
dc.creatorTorres, Carolina
dc.creatorMojsiejczuk, Laura
dc.creatorAcuña, Dolores
dc.creatorValinotto, Laura
dc.creatorGoya, Stephanie
dc.creatorNatale, Monica
dc.creatorAlexay, Sofia
dc.creatorAmadio, Ariel Fernando
dc.creatorIrazoqui, José Matías
dc.creatorFernández, Franco
dc.creatorAcevedo, Maria Elina
dc.creatorAlvarez Lopez, Cristina
dc.creatorAngelletti, Andres
dc.creatorAulicino, Paula
dc.creatorBolatti, Elisa María
dc.creatorBrusés, Bettina
dc.creatorCacciabue, Marco
dc.creatorCavatorta, Ana Laura
dc.creatorCerri, Agustina
dc.creatorCordero, Andres
dc.creatorDebat, Humberto
dc.creatorDus Santos, María José
dc.creatorEberhardt, María Florencia
dc.creatorErcole, Regina
dc.creatorEspul, Carlos
dc.creatorFarber, Marisa
dc.creatorFay, Fabián
dc.creatorFernández, María Ailén
dc.creatorFerrini, Florencia
dc.creatorFormichelli, Laura
dc.creatorCeballos, Santiago
dc.creatorGallego, Fernando
dc.creatorGiri, Adriana Angélica
dc.creatorGismondi, María Ines
dc.creatorAcevedo, Raul Maximiliano
dc.creatorGramundi, Iván
dc.creatorIbañez, María Eugenia
dc.creatorKönig, Guido Alberto
dc.creatorLeiva, Viviana
dc.creatorLorenzini Campos, Melina
dc.creatorLucero, Horacio
dc.creatorMarquez, Nathalie
dc.creatorMazzeo, Melina
dc.creatorMistchenko, Alicia Susana
dc.creatorMontoto, Luciana
dc.creatorMuñoz, Marianne
dc.creatorNadalich, Victoria
dc.creatorNardi, Cristina
dc.creatorOrtiz, Belén
dc.creatorPianciola, Luis
dc.creatorPintos, Carolina Beatriz
dc.creatorPuebla, Andrea Fabiana
dc.creatorRastellini, Carolina Victoria
dc.creatorRojas, Alejandro Ezequiel
dc.creatorSfalcin, Javier
dc.creatorSuárez, Ariel
dc.creatorTheaux, Clara
dc.creatorThomas, Guillermo
dc.creatorTittarelli, Estefanía
dc.creatorToro, Rosana
dc.creatorVillanova, Gabriela Vanina
dc.creatorWenk, Gretel
dc.creatorZiehm, María Cecilia
dc.creatorZimmermann, María Carla
dc.creatorZimmermann, María Carla
dc.creatorProyecto PAIS Working Group
dc.creatorViegas, Mariana
dc.date.accessioned2023-08-22T16:17:01Z
dc.date.available2023-08-22T16:17:01Z
dc.date.issued2023-06-16
dc.descriptionThe second wave of COVID-19 occurred in South America in early 2021 and was mainly driven by Gamma and Lambda variants. In this study, we aimed to describe the emergence and local genomic diversity of the SARS-CoV-2 Lambda variant in Argentina, from its initial entry into the country until its detection ceased. Molecular surveillance was conducted on 9356 samples from Argentina between October 2020 and April 2022, and sequencing, phylogenetic, and phylogeographic analyses were performed. Our findings revealed that the Lambda variant was first detected in Argentina in January 2021 and steadily increased in frequency until it peaked in April 2021, with continued detection throughout the year. Phylodynamic analyses showed that at least 18 introductions of the Lambda variant into the country occurred, with nine of them having evidence of onward local transmission. The spatial—temporal reconstruction showed that Argentine clades were associated with Lambda sequences from Latin America and suggested an initial diversification in the Metropolitan Area of Buenos Aires before spreading to other regions in Argentina. Genetic analyses of genome sequences allowed us to describe the mutational patterns of the Argentine Lambda sequences and detect the emergence of rare mutations in an immunocompromised patient. Our study highlights the importance of genomic surveillance in identifying the introduction and geographical distribution of the SARS-CoV-2 Lambda variant, as well as in monitoring the emergence of mutations that could be involved in the evolutionary leaps that characterize variants of concern.es
dc.description.filFil: Cavatorta, Ana Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Tecnología en Salud Pública; Argentina.
dc.description.sponsorshipMinisterio de Ciencia, Tecnología e Innovación (MINCyT): IP COVID-19 N°08
dc.description.sponsorshipFondo para la Convergencia Estructural del MERCOSUR: COF 03/11 COVID-19
dc.formatapplication/pdf
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/2133/26232
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://doi.org/10.3390/v15061382
dc.relation.publisherversionhttps://www.mdpi.com/1999-4915/15/6/1382
dc.rightsopenAccesses
dc.rights.holderNabaes Jodar, Mercedeses
dc.rights.holderTorres, Carolinaes
dc.rights.holderMojsiejczuk, Lauraes
dc.rights.holderAcuña, Doloreses
dc.rights.holderValinotto, Lauraes
dc.rights.holderGoya, Stephaniees
dc.rights.holderNatale, Monicaes
dc.rights.holderLusso, Silvinaes
dc.rights.holderAlexay, Sofiaes
dc.rights.holderAmadio, Ariel Fernandoes
dc.rights.holderIrazoqui, José Matíases
dc.rights.holderFernández, Francoes
dc.rights.holderAcevedo, Maria Elinaes
dc.rights.holderAlvarez Lopez, Cristinaes
dc.rights.holderAngelletti, Andreses
dc.rights.holderAulicino, Paulaes
dc.rights.holderBolatti, Elisa Maríaes
dc.rights.holderBrusés, Bettinaes
dc.rights.holderCacciabue, Marcoes
dc.rights.holderCavatorta, Ana Lauraes
dc.rights.holderCerri, Agustinaes
dc.rights.holderCordero, Andreses
dc.rights.holderDebat, Humbertoes
dc.rights.holderDus Santos, María Josées
dc.rights.holderEberhardt, María Florenciaes
dc.rights.holderErcole, Reginaes
dc.rights.holderEspul, Carloses
dc.rights.holderFarber, Marisaes
dc.rights.holderFay, Fabiánes
dc.rights.holderFernández, María Ailénes
dc.rights.holderFerrini, Florenciaes
dc.rights.holderFormichelli, Lauraes
dc.rights.holderCeballos, Santiagoes
dc.rights.holderGallego, Fernandoes
dc.rights.holderGiri, Adriana Angélicaes
dc.rights.holderGismondi, María Ineses
dc.rights.holderAcevedo, Raul Maximilianoes
dc.rights.holderGramundi, Ivánes
dc.rights.holderIbañez, María Eugeniaes
dc.rights.holderKönig, Guido Albertoes
dc.rights.holderLeiva, Vivianaes
dc.rights.holderLorenzini Campos, Melinaes
dc.rights.holderLucero, Horacioes
dc.rights.holderMarquez, Nathaliees
dc.rights.holderMazzeo, Melinaes
dc.rights.holderMistchenko, Alicia Susanaes
dc.rights.holderMontoto, Lucianaes
dc.rights.holderMuñoz, Mariannees
dc.rights.holderNadalich, Victoriaes
dc.rights.holderNardi, Cristinaes
dc.rights.holderOrtiz, Belénes
dc.rights.holderPianciola, Luises
dc.rights.holderPintos, Carolina Beatrizes
dc.rights.holderPuebla, Andrea Fabianaes
dc.rights.holderRastellini, Carolina Victoriaes
dc.rights.holderRojas, Alejandro Ezequieles
dc.rights.holderSfalcin, Javieres
dc.rights.holderSuárez, Arieles
dc.rights.holderTheaux, Claraes
dc.rights.holderThomas, Guillermoes
dc.rights.holderTittarelli, Estefaníaes
dc.rights.holderToro, Rosanaes
dc.rights.holderVillanova, Gabriela Vaninaes
dc.rights.holderWenk, Greteles
dc.rights.holderZiehm, María Ceciliaes
dc.rights.holderZimmermann, María Carlaes
dc.rights.holderZunino, Sebastiánes
dc.rights.holderProyecto PAIS Working Groupes
dc.rights.holderViegas, Marianaes
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSARS-CoV-2es
dc.subjectLambdaes
dc.subjectVariantses
dc.subjectEvolutiones
dc.subjectSouth Americaes
dc.subjectPhylodynamices
dc.titleThe lambda variant in Argentina: analyzing the evolution and spread of SARS-CoV-2 lineage C.37es
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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(FBIOyF) Departamento de Microbiología - Artículos
Colección Especial Coronavirus COVID-19