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WNT signaling in neuronal maturation and synaptogenesis

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dc.citation.titleFrontiers in Cellular Neuroscience
dc.citation.volume7
dc.creatorRosso, Silvana Beatriz
dc.creatorInestrosa, Nibaldo C.
dc.date.accessioned2024-05-20T12:26:46Z
dc.date.available2024-05-20T12:26:46Z
dc.date.issued2013-07-04
dc.description.abstractThe Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system. Wnt components are key regulators of a variety of developmental processes, including embryonic patterning, cell specification, and cell polarity. In the nervous system, Wnt signaling also regulates the formation and function of neuronal circuits by controlling neuronal differentiation, axon outgrowth and guidance, dendrite development, synaptic function, and neuronal plasticity. Wnt factors can signal through three very well characterized cascades: canonical or β-catenin pathway, planar cell polarity pathway and calcium pathway that control different processes. However, divergent downstream cascades have been identified to control neuronal morphogenesis. In the nervous system, the expression of Wnt proteins is a highly controlled process. In addition, deregulation of Wnt signaling has been associated with neurodegenerative diseases. Here, we will review different aspects of neuronal and dendrite maturation, including spinogenesis and synaptogenesis. Finally, the role of Wnt pathway components on Alzheimer’s disease will be revised.
dc.description.filFil: Rosso, Silvana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina.
dc.description.filFil: Rosso, Silvana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina. Fil: Inestrosa, Nibaldo C. Pontificia Universidad Católica de Chile. Facultad de Ciencias Biológicas. Centro de Envejecimiento y Regeneración. Departamento de Biología Celular y Molecular; Chile.
dc.description.sponsorshipBasal Center of Excellence in Science and Technology: PFB12/2007
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 227
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP 2012-0947
dc.format.extent1-11
dc.identifier.issn1662-5102
dc.identifier.urihttps://hdl.handle.net/2133/27067
dc.language.isoen
dc.publisherFrontiers Media
dc.relation.publisherversionhttps://doi.org/10.3389/fncel.2013.00103
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fncel.2013.00103/full
dc.rightsopenAccess
dc.rights.holderRosso, Silvana Beatriz
dc.rights.holderInestrosa, Nibaldo C.
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectWnt factors
dc.subjectNeuronal development
dc.subjectDendrite
dc.subjectSynapses
dc.subjectAlzheimer disease
dc.titleWNT signaling in neuronal maturation and synaptogenesis
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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