Photocatalytic C-H functionalization of nitrogen heterocycles mediated by a redox active protecting group
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Date
2023-08-31
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley and Sons Inc
Abstract
Description
Herein, we report a photocatalytic strategy for the C−H functionalization of saturated azaheterocycles under mild conditions with only one equivalent of starting material. Our strategy is based on a redox active benzamide protecting group that is activated via a halogen-atom transfer (XAT) process to trigger the formation of an α-amino radical. This nucleophilic radical intermediate was then engaged in Giese additions and radical cross couplings to afford C−H alkylated and arylated products.
Keywords
Azaheterocycles, C−H functionalization, Halogen atom transfer, Hydrogen atom transfer, Photoredox catalysis